TOR-4 Activity Description

Activity Title TOR-4

Activity ID: 38275

Activity Title: Upon request from WHO, to assist WHO with measurement of disease burden and mortality from alcohol associated liver disease and non-alcoholic fatty liver diseases including complications of cirrhosis, liver failure and liver cancer.

Link to TOR: TOR4

Name(s) of responsible staff at the institution: Dr S. K. Sarin, Dr. Manoj Sharma, Dr. Mohit Varshney, Dr. S.M.Shastry, Dr. Ashok Choudhary.

Type of activity: Collection and collation of information

Why WHO is asking for this activity and how WHO will use the deliverables? : Measuring disease burden and mortality from alcohol-associated liver disease and non-alcoholic fatty liver is important because it can help to identify the extent of these rapidly growing problems and the need for interventions.

It can also help to monitor trends over time and evaluate the effectiveness of interventions.
Understanding of contribution of alcohol to development of cirrhosis, liver failure and liver cancer has both preventive and therapeutic implications.

The possibilities of developing practical and acceptable guidance on liver transplantation in patients with alcohol associated liver diseases.

Use of alcohol in young people and its impact on the liver disease and hepatitis flare will be assessed. This will contribute to development of WHO guidance in this regard and will help in taking suitable measures to scale up the efforts and budgetary changes if needed. WHO will also use the information to propose liver health approaches integrated to universal health coverage (UHC).

What concrete actions will be taken by the designated institution? Be specific. : Under WHO’s leadership, the proposed collaborating centre will liaise with leading institutes and network of other cc to determine the role of alcohol and non-alcoholic fatty liver as the attributable fraction of cirrhosis and HCC to the national mortality data. It will collect, analyse and interpret the data as to evaluate the impact of alcohol associated liver disease and AUD on mortality and national economy.

What will be WHO’s role in this activity? : WHO will lead the activity and liaise with the proposed collaborating centre and support them in getting the data from different available sources ( registries/survey studies etc) in the member states.

Expected deliverables: Detailed report on Information on relative contribution of alcohol and non-alcoholic fatty liver disease (NAFLD) and other aetiologies such as hepatitis B virus (HBV), hepatitis C virus (HCV), autoimmune and other causes to the occurrence of chronic liver diseases (cirrhosis and hepatocellular carcinoma {HCC]).

Intellectual property rights: IP rights of ALL deliverables belong to WHO as per paragraphs 3.1.2 and/or 3.2.2 of the Terms and Conditions

Name(s) of funding sources: Govt of India and Institutional funds.

Activity timeframe: 2025

This activity has been specifically developed for the workplan of the WHO collaborating centre and does not constitute a standard activity of the institution without WHO involvement.